Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 7/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.56 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 7/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | NNMT | P40261 | 1/20 | 0.34 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13734783 | 1.00 | MAPK8 (0.56) | MAPK8MAPK9JAK2JAK1JAK3 | |
| SCHEMBL13740703 | 0.91 | MAPK8 (0.49) | MAPK8MAPK9JAK2JAK1JAK3 | |
| SCHEMBL26626510 | 0.88 | MAPK8 (0.54) | MAPK8MAPK9JAK2JAK1JAK3 | |
| SCHEMBL23244417 | 0.87 | SYK (0.42) | MAPK8MAPK9JAK2JAK1JAK3 | |
| SCHEMBL16932224 | 0.79 | MAPK8 (0.60) | MAPK8MAPK9JAK2JAK1JAK3 | |
| SCHEMBL13735566 | 0.79 | MAPK8 (0.57) | MAPK8MAPK9JAK2JAK1JAK3 | |
| SCHEMBL21554025 | 0.78 | SYK (0.63) | MAPK8JAK2JAK1JAK3SYK | |
| SCHEMBL14657467 | 0.77 | NNMT (0.41) | MAPK8MAPK9JAK2JAK1JAK3 | |
| SCHEMBL13735202 | 0.77 | MAPK8 (0.55) | MAPK8MAPK9JAK2JAK1JAK3 | |
| SCHEMBL21066965 | 0.75 | MAPK8 (0.56) | MAPK8MAPK9JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4328223-A2 | SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | Signal Pharmaceuticals, LLC (US) | 2024-02-28 | — | — | EP | disclosed |