SCHEMBL30801638

SCHEMBL30801638

O=C1CCC(N2Cc3cc(-c4sncc4-c4ccccc4)ccc3C2=O)C(=O)N1

nearest known ligand 0.57

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 8/20 0.57
IKZF1 Q13422 3/20 0.55
CSNK1A1 P48729 1/20 0.54
IKZF2 Q9UKS7 8/20 0.51
MAP1LC3B Q9GZQ8 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27217269 1.00 CRBN (0.57) CRBNIKZF1CSNK1A1IKZF2MAP1LC3B
SCHEMBL25123250 0.85 CRBN (0.71) CRBNIKZF1CSNK1A1IKZF2MAP1LC3B
SCHEMBL30801630 0.83 CRBN (0.63) CRBNIKZF1CSNK1A1IKZF2MAP1LC3B
SCHEMBL27216891 0.83 CRBN (0.63) CRBNIKZF1CSNK1A1IKZF2MAP1LC3B
SCHEMBL27310699 0.82 CRBN (0.56) CRBNIKZF1CSNK1A1IKZF2MAP1LC3B
SCHEMBL27310836 0.81 CRBN (0.55) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL30930614 0.81 CRBN (0.59) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL27283347 0.81 CRBN (0.59) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL30801568 0.80 CRBN (0.56) CRBNIKZF1CSNK1A1IKZF2MAP1LC3B
SCHEMBL27217194 0.80 CRBN (0.56) CRBNIKZF1CSNK1A1IKZF2MAP1LC3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4584259-A1 CK1ALPHA AND DUAL CK1ALPHA / GSPT1 DEGRADING COMPOUNDS Innovo Therapeutics, Inc. (US) 2025-07-16 EP disclosed
US-20240158370-A1 CK1 alpha AND DUAL CK1 alpha / GSPT1 DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. 2024-05-16 US disclosed
WO-2024054832-A1 CK1α AND DUAL CK1α / GSPT1 DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. (US) 2024-03-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240158370-A1 CK1 alpha AND DUAL CK1 alpha / GSPT1 DEGRADING COMPOUNDS CKS1B, CKS2, MARK1 CRBN 764/4885IKZF1 3493/4885CSNK1A1 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.