Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.69 |
| ▸ | CDK2 | P24941 | 1/20 | 0.69 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.69 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.69 |
| ▸ | PDE5A | O76074 | 16/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.59 |
| ▸ | METAP1 | P53582 | 2/20 | 0.57 |
| ▸ | METAP2 | P50579 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 7/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2175033 | 1.00 | CDK1 (0.69) | CDK1CDK2MKNK1MKNK2PDE5A | |
| SCHEMBL913494 | 0.85 | PDE5A (0.68) | CDK1CDK2MKNK1MKNK2PDE5A | |
| SCHEMBL27878086 | 0.83 | PDE5A (0.56) | PDE5AAURKANUDT1METAP1METAP2 | |
| SCHEMBL992234 | 0.82 | PDE5A (0.52) | CDK1CDK2MKNK1MKNK2PDE5A | |
| SCHEMBL222463 | 0.82 | CDK1 (1.00) | CDK1CDK2MKNK1MKNK2METAP1 | |
| SCHEMBL30874481 | 0.82 | METAP2 (0.55) | CDK1CDK2MKNK1MKNK2PDE5A | |
| SCHEMBL30874471 | 0.82 | CDK1 (1.00) | CDK1CDK2MKNK1MKNK2METAP1 | |
| SCHEMBL1170747 | 0.82 | METAP1 (0.72) | PDE5AAURKANUDT1METAP1METAP2 | |
| SCHEMBL7430084 | 0.79 | PDE5A (1.00) | PDE5AAURKAMETAP1METAP2PDE4A | |
| SCHEMBL9217011 | 0.79 | PDE5A (0.68) | PDE5AAURKAMETAP1METAP2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054512-A1 | AKT1 MODULATORS | ALTEROME THERAPEUTICS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |