Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27227037 | 0.85 | TDP1 (0.51) | TDP1MAPTMAPK1POLBNPC1 | |
| SCHEMBL20603986 | 0.85 | TDP1 (0.57) | TDP1MAPTMAPK1POLBNPC1 | |
| SCHEMBL2173703 | 0.85 | IGF1R (0.47) | TDP1MAPTMAPK1POLBNPC1 | |
| SCHEMBL30802397 | 0.83 | MAPT (0.43) | TDP1MAPTMAPK1POLBNPC1 | |
| SCHEMBL27878084 | 0.81 | MAPT (0.45) | TDP1MAPTMAPK1POLBNPC1 | |
| SCHEMBL10138757 | 0.81 | GSK3B (0.56) | TDP1MAPTMAPK1POLBKMT2A | |
| SCHEMBL30802494 | 0.80 | MAPT (0.63) | TDP1MAPTMAPK1NPC1NFKB1 | |
| SCHEMBL30802282 | 0.78 | SIGMAR1 (0.48) | TDP1MAPK1KMT2A | |
| SCHEMBL2964811 | 0.77 | AR (0.51) | TDP1MAPTNPC1RAB9AKMT2A | |
| SCHEMBL20603989 | 0.77 | TDP1 (0.50) | TDP1MAPTMAPK1POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054512-A1 | AKT1 MODULATORS | ALTEROME THERAPEUTICS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |