Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.47 |
| ▸ | MME | P08473 | 6/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.38 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7202874 | 0.89 | ACE (0.43) | ACEPTGS1SLC7A11GSTK1ANPEP | |
| SCHEMBL7202871 | 0.89 | ACE (0.43) | ACEPTGS1SLC7A11GSTK1ANPEP | |
| SCHEMBL21134741 | 0.87 | ACE (0.55) | ACEPTGS1SLC7A11GSTK1CA2 | |
| SCHEMBL16770231 | 0.87 | ACE (0.55) | ACEPTGS1SLC7A11GSTK1CA2 | |
| SCHEMBL30438134 | 0.86 | ACE (0.41) | ACEPTGS1SLC7A11GSTK1ANPEP | |
| SCHEMBL30437433 | 0.86 | ACE (0.41) | ACEPTGS1SLC7A11GSTK1ANPEP | |
| SCHEMBL29405310 | 0.86 | ACE (0.41) | ACEPTGS1SLC7A11GSTK1ANPEP | |
| SCHEMBL29402233 | 0.86 | ACE (0.41) | ACEPTGS1SLC7A11GSTK1ANPEP | |
| SCHEMBL29402083 | 0.86 | ACE (0.41) | ACEPTGS1SLC7A11GSTK1ANPEP | |
| SCHEMBL27820990 | 0.85 | MME (0.50) | TGFBR1MMEACEPTGS1SLC7A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3356386-B1 | METHOD OF TREATING MELANOCORTIN-4 RECEPTOR PATHWAY-ASSOCIATED DISORDERS | RHYTHM PHARMACEUTICALS INC (US) | 2024-02-14 | — | — | EP | claimed |