Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 4/20 | 0.40 |
| ▸ | CDK1 | P06493 | 4/20 | 0.40 |
| ▸ | CDK4 | P11802 | 4/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.40 |
| ▸ | CCND1 | P24385 | 4/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.40 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | CCND3 | P30281 | 4/20 | 0.40 |
| ▸ | CDK7 | P50613 | 4/20 | 0.40 |
| ▸ | CDK9 | P50750 | 4/20 | 0.40 |
| ▸ | CCNH | P51946 | 4/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.40 |
| ▸ | KDM5A | P29375 | 4/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30291202 | 0.81 | CDK1 (0.58) | CCNT1CDK1CDK4CCNB1CCND1 | |
| SCHEMBL31732415 | 0.80 | KDM5A (0.39) | CCNT1CDK1CDK4CCNB1CCND1 | |
| SCHEMBL29232088 | 0.70 | JAK2 (0.58) | CCNE1CDK2KDM5A | |
| SCHEMBL30291173 | 0.67 | CCNE1 (0.47) | CCNT1CDK1CDK4CCNB1CCND1 | |
| SCHEMBL20987206 | 0.67 | CDK4 (0.59) | CDK1CDK4CCND1CDK2CCND3 | |
| SCHEMBL30810371 | 0.67 | CCNE1 (0.59) | CCNT1CDK1CDK4CCNB1CCND1 | |
| SCHEMBL16010754 | 0.66 | TP53 (0.38) | CCNT1CDK1CCNB1CDK2CDK7 | |
| SCHEMBL1817312 | 0.64 | CSNK1A1 (0.51) | — | |
| SCHEMBL3554942 | 0.64 | CSNK1A1 (0.40) | — | |
| SCHEMBL29314874 | 0.64 | CDK1 (0.56) | CCNT1CDK1CDK4CCNB1CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250353842-A1 | BICYCLIC AMINE CDK12 INHIBITORS | INCYTE CORP (US) | 2025-11-20 | — | — | US | disclosed |
| WO-2023250430-A1 | BICYCLIC AMINE CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250353842-A1 | BICYCLIC AMINE CDK12 INHIBITORS | CDK12, CDK1, CDK2 | CCNT1 60/4885CDK1 2/4885CDK4 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.