SCHEMBL29314874

SCHEMBL29314874

CNc1ncc(C#N)c(-c2cnn(CC(F)(F)F)c2)n1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 9/20 0.56
CDK4 P11802 8/20 0.56
CCNB1 P14635 8/20 0.56
CCND1 P24385 8/20 0.56
CCNE1 P24864 8/20 0.56
CDK2 P24941 8/20 0.56
CCND3 P30281 8/20 0.56
CDK6 Q00534 8/20 0.56
CCNT1 O60563 6/20 0.56
CDK7 P50613 6/20 0.56
CDK9 P50750 6/20 0.56
CCNH P51946 6/20 0.56
MNAT1 P51948 6/20 0.56
IRAK4 Q9NWZ3 1/20 0.40
LRRK2 Q5S007 1/20 0.39
JAK2 O60674 5/20 0.39
TYK2 P29597 5/20 0.39
JAK1 P23458 4/20 0.39
STAT3 P40763 4/20 0.39
JAK3 P52333 4/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22900917 0.80 CDK2 (0.64) CDK1CDK4CCNB1CCND1CCNE1
SCHEMBL29314803 0.80 CDK1 (0.46) CDK1CDK4CCNB1CCND1CCNE1
SCHEMBL22900888 0.73 CCNE1 (1.00) CDK1CDK4CCNB1CCND1CCNE1
SCHEMBL22901170 0.71 CDK2 (1.00) CDK1CDK4CCNB1CCND1CCNE1
SCHEMBL29315373 0.70 KDR (0.48) CDK1CDK2CCNT1CDK9KDR
SCHEMBL30291185 0.69 CDK1 (0.53) CDK1CDK4CCNB1CCND1CCNE1
SCHEMBL30291202 0.68 CDK1 (0.58) CDK1CDK4CCNB1CCND1CCNE1
SCHEMBL29314691 0.67 ADORA1 (0.63) CDK1KDRADORA2AADORA1
SCHEMBL4561626 0.67 LRRK2 (0.60) LRRK2
SCHEMBL29314862 0.66 ADORA1 (0.64) CDK1KDRADORA2AADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3782986-B1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICALS CO (JP) 2024-07-10 EP disclosed