Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759492 | 0.93 | PDGFRA (0.45) | PDGFRACHRM1HRH3KITPOLQ | |
| SCHEMBL24576994 | 0.93 | PDGFRA (0.45) | PDGFRACHRM1HRH3KITPOLQ | |
| SCHEMBL30809550 | 0.92 | PDGFRA (0.42) | PDGFRACHRM1HRH3KITPOLQ | |
| SCHEMBL30809496 | 0.92 | PDGFRA (0.42) | PDGFRACHRM1HRH3KITPOLQ | |
| SCHEMBL30809503 | 0.91 | PDGFRA (0.43) | PDGFRACHRM1HRH3KITPOLQ | |
| SCHEMBL30809528 | 0.91 | PDGFRA (0.41) | PDGFRACHRM1HRH3KITPOLQ | |
| SCHEMBL30809543 | 0.91 | PDGFRA (0.44) | PDGFRACHRM1HRH3KITPOLQ | |
| SCHEMBL30809558 | 0.90 | PDGFRA (0.41) | PDGFRACHRM1HRH3KITPOLQ | |
| SCHEMBL30809529 | 0.89 | PDGFRA (0.44) | PDGFRACHRM1HRH3KITPOLQ | |
| SCHEMBL30809510 | 0.89 | PDGFRA (0.40) | PDGFRACHRM1HRH3KITPOLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | claimed |