Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 2/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30809496 | 0.96 | PDGFRA (0.42) | PDGFRACHRM1HRH3POLQKIT | |
| SCHEMBL30809490 | 0.92 | PDGFRA (0.44) | PDGFRACHRM1HRH3POLQKIT | |
| SCHEMBL30809528 | 0.91 | PDGFRA (0.41) | PDGFRACHRM1HRH3POLQKIT | |
| SCHEMBL24576994 | 0.90 | PDGFRA (0.45) | PDGFRACHRM1HRH3POLQKIT | |
| SCHEMBL29759492 | 0.90 | PDGFRA (0.45) | PDGFRACHRM1HRH3POLQKIT | |
| SCHEMBL30809478 | 0.89 | PDGFRA (0.43) | PDGFRACHRM1HRH3POLQKIT | |
| SCHEMBL29760054 | 0.88 | PDGFRA (0.41) | PDGFRACHRM1HRH3POLQKIT | |
| SCHEMBL30809543 | 0.88 | PDGFRA (0.44) | PDGFRACHRM1HRH3POLQKIT | |
| SCHEMBL24578004 | 0.88 | PDGFRA (0.41) | PDGFRACHRM1HRH3POLQKIT | |
| SCHEMBL30809553 | 0.87 | PDGFRA (0.43) | PDGFRACHRM1HRH3POLQKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | claimed |