Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | CSK | P41240 | 1/20 | 0.31 |
| ▸ | GPR6 | P46095 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30809573 | 0.89 | WNT1 (0.34) | WNT1GSK3BDYRK1ACHRM1PDGFRA | |
| SCHEMBL30809580 | 0.89 | CHRM1 (0.37) | CHRM1PDGFRAHRH3LCKCSK | |
| SCHEMBL30809493 | 0.88 | WNT1 (0.32) | WNT1GSK3BDYRK1ACHRM1PDGFRA | |
| SCHEMBL27185015 | 0.85 | WNT1 (0.38) | WNT1GSK3BDYRK1ACHRM1PDGFRA | |
| SCHEMBL29760098 | 0.85 | WNT1 (0.38) | WNT1GSK3BDYRK1ACHRM1PDGFRA | |
| SCHEMBL24579107 | 0.85 | WNT1 (0.35) | WNT1GSK3BDYRK1ACHRM1PDGFRA | |
| SCHEMBL29760014 | 0.85 | WNT1 (0.35) | WNT1GSK3BDYRK1ACHRM1PDGFRA | |
| SCHEMBL24579122 | 0.85 | WNT1 (0.35) | WNT1GSK3BDYRK1ACHRM1PDGFRA | |
| SCHEMBL29759698 | 0.85 | WNT1 (0.35) | WNT1GSK3BDYRK1ACHRM1PDGFRA | |
| SCHEMBL24579072 | 0.85 | WNT1 (0.35) | WNT1GSK3BDYRK1ACHRM1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | claimed |
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |