Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 16/20 | 0.44 |
| ▸ | JAK2 | O60674 | 12/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23668175 | 0.84 | JAK1 (0.43) | JAK1JAK2LRRK2CDK2CDK9 | |
| SCHEMBL30810104 | 0.83 | JAK1 (0.43) | JAK1JAK2 | |
| SCHEMBL23678830 | 0.79 | JAK1 (0.44) | JAK1JAK2LRRK2JAK3KCNH2 | |
| SCHEMBL23668192 | 0.76 | JAK1 (0.47) | JAK1JAK2LRRK2JAK3KCNH2 | |
| SCHEMBL23668179 | 0.73 | LRRK2 (0.52) | JAK1JAK2LRRK2JAK3KCNH2 | |
| SCHEMBL23668178 | 0.71 | FLT3 (0.42) | JAK1JAK2CDK2JAK3 | |
| SCHEMBL30018373 | 0.70 | JAK1 (0.44) | JAK1JAK2 | |
| SCHEMBL28932573 | 0.70 | JAK1 (0.44) | JAK1JAK2 | |
| SCHEMBL23678817 | 0.70 | JAK1 (0.47) | JAK1JAK2LRRK2JAK3KCNH2 | |
| SCHEMBL21870747 | 0.69 | LRRK2 (0.60) | JAK1JAK2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112823159-B | Aromatic heterocyclic compounds with kinase inhibitory activity | 上海轶诺药业有限公司 | 2024-03-01 | — | — | CN | disclosed |