Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 10/20 | 0.50 |
| ▸ | CDK2 | P24941 | 10/20 | 0.50 |
| ▸ | CDK1 | P06493 | 8/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.49 |
| ▸ | CDK4 | P11802 | 7/20 | 0.49 |
| ▸ | CCND1 | P24385 | 7/20 | 0.49 |
| ▸ | CCND3 | P30281 | 7/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 7/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.49 |
| ▸ | CDK7 | P50613 | 3/20 | 0.49 |
| ▸ | CDK9 | P50750 | 3/20 | 0.49 |
| ▸ | CCNH | P51946 | 3/20 | 0.49 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.49 |
| ▸ | IDH1 | O75874 | 2/20 | 0.46 |
| ▸ | IDH2 | P48735 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22977511 | 0.86 | IDH1 (0.48) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL27213273 | 0.81 | IDH1 (0.48) | IDH1IDH2SYKGPR119ALK | |
| SCHEMBL22900783 | 0.81 | JAK1 (0.54) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL29926869 | 0.81 | JAK1 (0.54) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL30810431 | 0.81 | CCNE1 (0.69) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL29821059 | 0.81 | IDH1 (0.49) | CCNT1IDH1IDH2SYKGPR119 | |
| SCHEMBL22901094 | 0.81 | IDH1 (0.49) | CCNT1IDH1IDH2SYKGPR119 | |
| SCHEMBL22977446 | 0.81 | GPR119 (0.49) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL30357709 | 0.81 | GPR119 (0.44) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL22977174 | 0.81 | GPR119 (0.44) | CCNE1CDK2CDK1CCNB1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543861-A1 | BIFUNCTIONAL COMPOUNDS CONTAINING PYRIMIDINE DERIVATIVES FOR DEGRADING CYCLIN-DEPENDENT KINASE 2 VIA UBIQUITIN PROTEASOME PATHWAY | Nikang Therapeutics, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| CN-119630644-A | Bifunctional compounds containing pyrimidine derivatives for degradation of cyclin-dependent kinase 2 via the ubiquitin proteasome pathway | 霖康疗法公司 | 2025-03-14 | — | — | CN | disclosed |
| WO-2023249970-A1 | BIFUNCTIONAL COMPOUNDS CONTAINING PYRIMIDINE DERIVATIVES FOR DEGRADING CYCLIN-DEPENDENT KINASE 2 VIA UBIQUITIN PROTEASOME PATHWAY | NIKANG THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |