Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.60 |
| ▸ | MEN1 | O00255 | 10/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | POLB | P06746 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | THRB | P10828 | 2/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24554021 | 1.00 | MAPT (0.60) | MAPTMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL29871174 | 0.87 | MAPT (0.51) | MAPTMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL30811098 | 0.87 | MAPT (0.51) | MAPTMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL24553605 | 0.87 | MAPT (0.51) | MAPTMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL24554078 | 0.84 | MAPT (0.56) | MAPTMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL24554020 | 0.81 | MAPT (0.48) | MAPTMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL30811105 | 0.81 | MAPT (0.48) | MAPTMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL12351215 | 0.75 | MAPT (0.65) | MAPTMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL27983608 | 0.75 | MAPT (0.82) | MAPTMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL27983250 | 0.72 | MAPT (1.00) | MAPTMEN1KMT2ASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112538078-B | Polycyclic compound for inhibiting DHX33 helicase | 成都开悦生命科技有限公司 | 2024-03-19 | — | — | CN | disclosed |