SCHEMBL30820641

SCHEMBL30820641

O=C(C#Cc1ccccc1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O

nearest known ligand 0.60

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 10/20 0.60
DDB1 Q16531 3/20 0.60
GSPT1 P15170 2/20 0.60
CYP2C19 P33261 1/20 0.60
KCNH2 Q12809 1/20 0.60
IKZF3 Q9UKT9 1/20 0.59
CSNK1A1 P48729 2/20 0.57
IKZF2 Q9UKS7 7/20 0.54
IKZF1 Q13422 2/20 0.50
MAP1LC3B Q9GZQ8 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24847358 1.00 CRBN (0.60) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24848224 0.95 CRBN (0.57) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24847669 0.93 CRBN (0.55) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24848167 0.93 CRBN (0.58) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24848011 0.92 CRBN (0.58) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24847729 0.92 CRBN (0.62) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24848177 0.92 CRBN (0.56) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24847696 0.92 CRBN (0.57) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24847420 0.91 CRBN (0.60) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24847357 0.91 CRBN (0.61) CRBNDDB1GSPT1CYP2C19KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117683022-A Amide compound and preparation method and application thereof 北京医院 2024-03-12 CN disclosed