Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HEXA | P06865 | 1/20 | 0.36 |
| ▸ | HEXB | P07686 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 3/20 | 0.30 |
| ▸ | RAB9A | P51151 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30822663 | 0.82 | BACE1 (0.33) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL30822656 | 0.75 | PIK3CD (0.42) | — | |
| SCHEMBL29164684 | 0.75 | PIK3CD (0.42) | — | |
| SCHEMBL29164686 | 0.75 | PIK3CD (0.42) | — | |
| SCHEMBL30822700 | 0.72 | JAK2 (0.37) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL30822687 | 0.70 | JAK2 (0.39) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL30541884 | 0.68 | POLB (0.45) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL30822667 | 0.68 | JAK2 (0.39) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL30822652 | 0.68 | JAK2 (0.39) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL31743137 | 0.66 | MAPT (0.42) | MEN1KMT2AMAPTMAPK1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117659001-A | Aminopyrimidine derivatives and their use in medicine | 广东东阳光药业股份有限公司 | 2024-03-08 | — | — | CN | disclosed |