Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30822668 | 0.85 | CYP1A2 (0.35) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL30822667 | 0.85 | JAK2 (0.39) | JAK2JAK1TYK2JAK3GAA | |
| SCHEMBL30822666 | 0.84 | JAK2 (0.37) | JAK2JAK1TYK2JAK3GAA | |
| SCHEMBL30822701 | 0.84 | JAK2 (0.37) | JAK2JAK1TYK2JAK3GAA | |
| SCHEMBL30822735 | 0.81 | JAK2 (0.37) | JAK2JAK1TYK2JAK3EGFR | |
| SCHEMBL30822700 | 0.81 | JAK2 (0.37) | JAK2JAK1TYK2JAK3GAA | |
| SCHEMBL30822711 | 0.81 | CCNA2 (0.39) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL30822687 | 0.77 | JAK2 (0.39) | JAK2JAK1TYK2JAK3GAA | |
| SCHEMBL30822741 | 0.74 | ALK (0.41) | JAK2GAAMAPTPARP1FEN1 | |
| SCHEMBL30822704 | 0.72 | ALK (0.36) | MAPTPARP1FEN1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117659001-A | Aminopyrimidine derivatives and their use in medicine | 广东东阳光药业股份有限公司 | 2024-03-08 | — | — | CN | disclosed |