Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 9/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30492130 | 0.71 | HCAR2 (0.41) | HCAR2SLC6A4 | |
| SCHEMBL23780176 | 0.69 | HCAR2 (0.57) | HCAR2SLC6A4KMT2ATSHR | |
| SCHEMBL21752518 | 0.69 | HCAR2 (0.57) | HCAR2SLC6A4KMT2ATSHR | |
| SCHEMBL4933770 | 0.69 | HCAR2 (0.44) | HCAR2SLC6A4 | |
| SCHEMBL22887755 | 0.66 | GAA (0.58) | RIPK1HCAR2GAANPC1RAB9A | |
| SCHEMBL22888174 | 0.66 | HCAR2 (0.43) | RIPK1HCAR2SLC6A4 | |
| SCHEMBL31707116 | 0.65 | SIGMAR1 (0.36) | HCAR2 | |
| SCHEMBL4481593 | 0.65 | HCAR2 (0.73) | HCAR2SLC6A4 | |
| SCHEMBL22888109 | 0.63 | GAA (0.52) | RIPK1HCAR2GAANPC1RAB9A | |
| SCHEMBL5083071 | 0.62 | HCAR2 (0.70) | HCAR2GAAKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760625-B1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | HOFFMANN LA ROCHE (CH) | 2024-03-27 | — | — | EP | claimed |