Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | GPR3 | P46089 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382006 | 1.00 | KDM4E (0.46) | KDM4ETLR8CYP1A2HTR3AHRH4 | |
| Hydrochloric Acid SCHEMBL28102802 | 0.98 | KDM4E (0.44) | KDM4ETLR8CYP1A2HTR3AHRH4 | |
| Hydrochloric Acid SCHEMBL28174209 | 0.98 | KDM4E (0.44) | KDM4ETLR8CYP1A2HTR3AHRH4 | |
| SCHEMBL3277330 | 0.83 | KDM4E (0.45) | KDM4ECYP1A2HTR3AHRH4GPR3 | |
| SCHEMBL27825404 | 0.81 | CYP1A2 (0.38) | KDM4ETLR8CYP1A2HTR3AHRH4 | |
| SCHEMBL28624806 | 0.80 | CYP1A2 (0.40) | KDM4ETLR8CYP1A2HTR3AHRH4 | |
| SCHEMBL3634933 | 0.80 | TLR8 (0.49) | KDM4ETLR8CYP1A2HTR3AHRH4 | |
| SCHEMBL30952029 | 0.80 | TLR8 (0.49) | KDM4ETLR8CYP1A2HTR3AHRH4 | |
| SCHEMBL716117 | 0.80 | TSHR (0.50) | KDM4ETLR8CYP1A2HTR3AHRH4 | |
| SCHEMBL5004880 | 0.79 | TLR8 (0.47) | KDM4ETLR8CYP1A2HTR3AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240067632-A1 | WEE1 Degrading Compounds and Uses Thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-02-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240067632-A1 | WEE1 Degrading Compounds and Uses Thereof | WEE1, WEE2, PPME1 | KDM4E 376/4885TLR8 3951/4885CYP1A2 3456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.