Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | VDR | P11473 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | P4HB | P07237 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24581976 | 1.00 | KDM4E (0.46) | KDM4EFFAR1VDROPRK1KMT2A | |
| SCHEMBL12790220 | 0.83 | KDM4E (0.44) | KDM4EFFAR1KMT2AL3MBTL1HDAC4 | |
| SCHEMBL12847001 | 0.80 | SLC6A9 (0.44) | KDM4EFFAR1KMT2AALOX12 | |
| SCHEMBL30824561 | 0.80 | KDM4E (0.48) | KDM4EFFAR1KMT2ACYP2D6ALDH1A1 | |
| SCHEMBL24581974 | 0.80 | KDM4E (0.48) | KDM4EFFAR1KMT2ACYP2D6ALDH1A1 | |
| SCHEMBL24017128 | 0.66 | HDAC4 (0.47) | SLC6A2SLC6A4HDAC4HDAC7HDAC5 | |
| SCHEMBL24017037 | 0.66 | HDAC4 (0.47) | SLC6A2SLC6A4HDAC4HDAC7HDAC5 | |
| SCHEMBL12320076 | 0.65 | KDR (0.47) | KDM4EKMT2AALDH1A1HSD17B10HDAC4 | |
| SCHEMBL12874998 | 0.65 | KDM4E (0.50) | KDM4EFFAR1OPRK1KMT2ACYP2D6 | |
| SCHEMBL696487 | 0.65 | KDM4E (0.50) | KDM4EFFAR1OPRK1KMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | CYTOKINETICS, INC. | 2024-02-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | NAMPT, NNT, NAPRT | KDM4E 3301/4885FFAR1 1460/4885VDR 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.