Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 13/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR1F | P30939 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.37 |
| ▸ | ESRRA | P11474 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30824880 | 0.82 | PDE4D (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27391578 | 0.82 | PDE4D (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30824826 | 0.80 | UTS2R (0.34) | UTS2RHTR1ACYP2D6DRD2HTR1D | |
| SCHEMBL27391581 | 0.80 | UTS2R (0.34) | UTS2RHTR1ACYP2D6DRD2HTR1D | |
| SCHEMBL31245998 | 0.79 | NOTUM (0.44) | NOTUMCYP2D6ESRRAPDE4APDE4B | |
| SCHEMBL19404308 | 0.78 | UTS2R (0.48) | NOTUMUTS2RHTR2CHTR2B | |
| SCHEMBL16533471 | 0.76 | NOTUM (0.50) | NOTUMCYP2D6ESRRAPDE4APDE4B | |
| SCHEMBL27391576 | 0.74 | NOTUM (0.46) | NOTUMCYP2D6ESRRA | |
| SCHEMBL31246020 | 0.73 | NOTUM (0.43) | NOTUMESRRACHRNB2CHRNA4PDE4A | |
| SCHEMBL8154363 | 0.73 | PDE4B (0.50) | NOTUMPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054955-A1 | HETEROBIFUNCTIONAL COMPOUNDS AND METHODS OF TREATING DISEASE | HALDA THERAPEUTICS OPCO, INC. (US) | 2024-03-14 | — | — | WO | disclosed |