Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 7/20 | 0.70 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1291539 | 0.84 | AVPR2 (0.50) | AVPR2AVPR1ALMNANPC1MAPT | |
| SCHEMBL30824950 | 0.84 | AVPR2 (0.50) | AVPR2AVPR1ALMNANPC1MAPT | |
| SCHEMBL30354667 | 0.83 | AVPR2 (0.76) | AVPR2AVPR1AHDAC1HDAC6NOTUM | |
| SCHEMBL26406287 | 0.81 | AVPR2 (0.46) | AVPR2AVPR1ALMNANPC1MAPT | |
| SCHEMBL28475504 | 0.79 | AVPR2 (0.49) | AVPR2AVPR1ALMNANPC1HTT | |
| SCHEMBL8671412 | 0.78 | AVPR2 (0.67) | AVPR2LMNANPC1MAPTHTT | |
| SCHEMBL4680537 | 0.77 | AVPR2 (0.47) | AVPR2AVPR1ALMNANPC1HTT | |
| SCHEMBL7355229 | 0.77 | AVPR2 (0.52) | AVPR2LMNANPC1MAPTHTT | |
| SCHEMBL7245901 | 0.77 | AVPR2 (0.73) | AVPR2AVPR1ALMNAHDAC1HDAC6 | |
| SCHEMBL5486199 | 0.77 | AVPR2 (0.47) | AVPR2AVPR1ALMNANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117624049-A | Method for synthesizing and refining key intermediate of tolvaptan | 山东科新药业有限公司 | 2024-03-01 | — | — | CN | claimed |
| CN-117624049-A | Method for synthesizing and refining key intermediate of tolvaptan | 山东科新药业有限公司 | 2024-03-01 | — | — | CN | disclosed |