Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352564 | 0.97 | AVPR2 (0.47) | AVPR2MAPTLMNAHTTNPC1 | |
| SCHEMBL7349526 | 0.90 | PAX8 (0.50) | AVPR2MAPTLMNAHTTNPC1 | |
| SCHEMBL7350088 | 0.88 | MAPT (0.53) | AVPR2MAPTLMNAHTTNPC1 | |
| SCHEMBL7345988 | 0.87 | HTT (0.50) | AVPR2MAPTLMNAHTTNPC1 | |
| SCHEMBL30824950 | 0.87 | AVPR2 (0.50) | AVPR2MAPTLMNAHTTNPC1 | |
| SCHEMBL7348930 | 0.87 | RAB9A (0.48) | MAPTLMNAHTTNPC1ALDH1A1 | |
| SCHEMBL1291539 | 0.87 | AVPR2 (0.50) | AVPR2MAPTLMNAHTTNPC1 | |
| SCHEMBL7352139 | 0.86 | AVPR2 (0.52) | AVPR2MAPTLMNAHTTNPC1 | |
| SCHEMBL7376092 | 0.85 | MAPT (0.52) | AVPR2MAPTLMNAHTTNPC1 | |
| SCHEMBL7350004 | 0.84 | AVPR2 (0.54) | AVPR2MAPTLMNAHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |