Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.43 |
| ▸ | ALKBH1 | Q13686 | 2/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL949676 | 0.84 | CREBBP (0.55) | EGLN1ALKBH1KLKB1CREBBPTDP1 | |
| SCHEMBL12913216 | 0.84 | CREBBP (0.55) | EGLN1ALKBH1KLKB1CREBBPTDP1 | |
| SCHEMBL947911 | 0.84 | CREBBP (0.55) | EGLN1ALKBH1KLKB1CREBBPTDP1 | |
| SCHEMBL31043465 | 0.83 | HTT (0.47) | ADRA1DKLKB1 | |
| SCHEMBL25911583 | 0.83 | HTT (0.47) | ADRA1DKLKB1 | |
| SCHEMBL31502175 | 0.83 | HTT (0.47) | ADRA1DKLKB1 | |
| SCHEMBL947800 | 0.76 | CREBBP (0.52) | ALKBH1KLKB1CREBBPTDP1 | |
| SCHEMBL949139 | 0.76 | CREBBP (0.52) | ALKBH1KLKB1CREBBPTDP1 | |
| SCHEMBL949190 | 0.76 | CREBBP (0.52) | ALKBH1KLKB1CREBBPTDP1 | |
| SCHEMBL15520641 | 0.75 | ACHE (0.44) | EGLN1ALKBH1KLKB1CREBBPL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146809-A9 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-03-14 | — | — | WO | disclosed |