Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 20/20 | 0.46 |
| ▸ | PLK3 | Q9H4B4 | 5/20 | 0.46 |
| ▸ | PLK2 | Q9NYY3 | 5/20 | 0.46 |
| ▸ | FLT3 | P36888 | 5/20 | 0.43 |
| ▸ | NEK6 | Q9HC98 | 2/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | MELK | Q14680 | 1/20 | 0.42 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30825160 | 0.92 | PLK1 (0.46) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL30900381 | 0.77 | SOS1 (0.39) | PLK1FLT3 | |
| SCHEMBL29226360 | 0.77 | PLK1 (0.41) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL29226363 | 0.73 | SIRT6 (0.42) | — | |
| SCHEMBL30900433 | 0.71 | PLK1 (0.57) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL29226213 | 0.71 | PLK1 (0.57) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL30825152 | 0.70 | ALK (0.46) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL29226256 | 0.69 | PLK1 (0.59) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL15859003 | 0.68 | MAPT (0.43) | — | |
| SCHEMBL30825086 | 0.68 | PLK1 (0.45) | PLK1PLK3PLK2FLT3NEK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024051717-A1 | COMPOUND AS PLK1 INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海深势唯思科技有限责任公司 | 2024-03-14 | — | — | WO | disclosed |