Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29832687 | 1.00 | METAP2 (0.53) | METAP2KDM4EMEN1NPC1TP53 | |
| SCHEMBL6424414 | 1.00 | METAP2 (0.53) | METAP2KDM4EMEN1NPC1TP53 | |
| SCHEMBL30322896 | 0.77 | MEN1 (0.47) | METAP2KDM4EMEN1NPC1TP53 | |
| SCHEMBL30011414 | 0.77 | METAP2 (0.46) | METAP2KDM4ENPC1CYP3A4CYP2D6 | |
| SCHEMBL27174135 | 0.77 | METAP2 (0.46) | METAP2KDM4ENPC1CYP3A4CYP2D6 | |
| SCHEMBL69894 | 0.77 | MEN1 (0.47) | METAP2KDM4EMEN1NPC1TP53 | |
| SCHEMBL51294 | 0.77 | METAP2 (0.46) | METAP2KDM4ENPC1CYP3A4CYP2D6 | |
| SCHEMBL13171944 | 0.77 | TDP1 (0.35) | METAP2KDM4EMEN1CYP2C19KMT2A | |
| SCHEMBL17264311 | 0.77 | KMT2A (0.45) | KDM4EMEN1TP53CYP3A4CYP2D6 | |
| SCHEMBL29360004 | 0.77 | METAP2 (0.46) | METAP2KDM4ENPC1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117618429-A | Application of deubiquitinase USP 8inhibitor in preparation of medicines for treating Japanese encephalitis | 中国人民解放军海军军医大学 | 2024-03-01 | — | — | CN | disclosed |