Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | MAPK6 | Q16659 | 7/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.37 |
| ▸ | CDK9 | P50750 | 5/20 | 0.37 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | CCND1 | P24385 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27252149 | 1.00 | DDB1 (0.43) | DDB1CRBNMAPK6CCNT1CDK9 | |
| SCHEMBL30825858 | 1.00 | DDB1 (0.43) | DDB1CRBNMAPK6CCNT1CDK9 | |
| Hydrochloric Acid SCHEMBL30825919 | 0.98 | DDB1 (0.42) | DDB1CRBNMAPK6CCNT1CDK9 | |
| SCHEMBL2369405 | 0.84 | DDB1 (0.51) | DDB1CRBNCCNKCDK12HCAR3 | |
| SCHEMBL25490042 | 0.81 | MAPK6 (0.44) | MAPK6CCNKCDK12HCAR3 | |
| SCHEMBL30825861 | 0.81 | PDGFRB (0.40) | MAPK6CCNT1CDK9CDK4CCND1 | |
| SCHEMBL27260999 | 0.81 | MAPK6 (0.39) | MAPK6CCNT1CDK9CDK4CCND1 | |
| SCHEMBL27260540 | 0.81 | PDGFRB (0.40) | MAPK6CCNT1CDK9CDK4CCND1 | |
| SCHEMBL29312307 | 0.81 | MAPK6 (0.44) | MAPK6CCNKCDK12HCAR3 | |
| SCHEMBL21503404 | 0.78 | HCRTR1 (0.44) | MAPK6CCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4590396-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | Astrazeneca AB (SE) | 2025-07-30 | — | — | EP | disclosed |
| US-20240217951-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2024-07-04 | — | — | US | disclosed |
| WO-2024062089-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2024-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240217951-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | PCSK9, PCSK7, PCSK6 | DDB1 1235/4885CRBN 1733/4885MAPK6 2782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.