Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 3/20 | 0.37 |
| ▸ | TTK | P33981 | 3/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 3/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4982636 | 0.91 | PIM1 (0.44) | OPRM1OPRD1OPRK1OPRL1MEN1 | |
| SCHEMBL10284065 | 0.79 | KMT2A (0.70) | OPRM1OPRD1OPRK1OPRL1MEN1 | |
| SCHEMBL3341266 | 0.76 | KDM4E (0.40) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL3345983 | 0.72 | NR4A2 (0.43) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL28285317 | 0.72 | MEN1 (0.82) | OPRM1OPRD1OPRK1OPRL1MEN1 | |
| SCHEMBL308725 | 0.68 | MEN1 (0.36) | OPRM1OPRD1OPRK1OPRL1MEN1 | |
| SCHEMBL3357845 | 0.67 | OPRM1 (0.49) | OPRM1OPRD1OPRK1OPRL1MEN1 | |
| SCHEMBL3339082 | 0.67 | KDM4E (0.43) | KMT2AKDM4EALDH1A1LMNAPOLB | |
| SCHEMBL17846549 | 0.67 | MEN1 (0.58) | OPRM1OPRD1OPRK1OPRL1MEN1 | |
| SCHEMBL28914037 | 0.66 | MEN1 (0.60) | OPRM1OPRD1OPRK1OPRL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111406-B1 | SUBSTITUTED SPIROCHROMANONE DERIVATIVES AS ACC INHIBITORS | MERCK SHARP & DOHME (US) | 2012-10-24 | — | — | EP | disclosed |
| US-8093389-B2 | e.g. 1-[(1-Ethyl-4-methoxy-1H-benzimidazol-6-yl)carbonyl]-6-(1H-tetrazol-5-yl)spiro[chroman-2,4'-piperidine]-4-one; acetyl CoA carboxylase inhibitors; antidiabetic, hypoglycemic agent; metabolic syndrome, fatty liver, hyperlipemia, obesity, diabetes, bulimia, malignant neoplasm or infectious diseases | MERCK SHARP & DOHME CORP. (US) | 2012-01-10 | — | — | US | disclosed |
| US-20080171761-A1 | Substituted spirochromanone derivatives | MERCK SHARP & DOHME LLC | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171761-A1 | Substituted spirochromanone derivatives | CBR3, CBR1, CNKSR1 | OPRM1 760/4885OPRD1 706/4885OPRK1 301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.