Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 3/20 | 0.39 |
| ▸ | ARG2 | P78540 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30827370 | 1.00 | ARG1 (0.39) | ARG1ARG2NPSR1MAPTCYP4F2 | |
| SCHEMBL30827366 | 1.00 | ARG1 (0.39) | ARG1ARG2NPSR1MAPTCYP4F2 | |
| SCHEMBL27198590 | 1.00 | ARG1 (0.39) | ARG1ARG2NPSR1MAPTCYP4F2 | |
| SCHEMBL28592319 | 0.86 | ARG1 (0.39) | ARG1ARG2GAAMEN1KMT2A | |
| SCHEMBL27198621 | 0.80 | ARG1 (0.57) | ARG1ARG2 | |
| SCHEMBL2906017 | 0.80 | ARG1 (0.57) | ARG1ARG2 | |
| SCHEMBL27198574 | 0.80 | ARG1 (0.57) | ARG1ARG2 | |
| SCHEMBL31440740 | 0.80 | ARG1 (0.57) | ARG1ARG2 | |
| Hydrochloric Acid SCHEMBL1806885 | 0.79 | ARG1 (0.55) | ARG1ARG2 | |
| Bromide SCHEMBL27198559 | 0.79 | ARG1 (0.55) | ARG1ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4590675-B1 | HETEROCYCLIC SIK INHIBITORS | PFIZER (US) | 2026-05-27 | — | — | EP | disclosed |
| EP-4590675-A1 | HETEROCYCLIC SIK INHIBITORS | Pfizer Inc. (US) | 2025-07-30 | — | — | EP | disclosed |
| US-20240124450-A1 | Novel SIK Inhibitors | PFIZER INC. (US) | 2024-04-18 | — | — | US | disclosed |
| WO-2024062360-A1 | HETEROCYCLIC SIK INHIBITORS | PFIZER INC. (US) | 2024-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124450-A1 | Novel SIK Inhibitors | SIK3, SIK2, SIK1 | ARG1 1737/4885ARG2 4022/4885NPSR1 1134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.