Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 9/20 | 0.36 |
| ▸ | LCK | P06239 | 7/20 | 0.36 |
| ▸ | BTK | Q06187 | 3/20 | 0.36 |
| ▸ | DPP4 | P27487 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24834051 | 1.00 | KDM4E (0.38) | KDM4EMEN1NPC1TP53ALOX15 | |
| SCHEMBL24834042 | 0.90 | KDM4E (0.39) | KDM4EMEN1NPC1TP53ALOX15 | |
| SCHEMBL24833597 | 0.87 | JAK3 (0.40) | JAK3LCKBTKDPP4KDM1A | |
| SCHEMBL30160648 | 0.78 | JAK3 (0.42) | JAK3LCKBTKEGFR | |
| SCHEMBL24833599 | 0.78 | JAK3 (0.42) | JAK3LCKBTKEGFR | |
| SCHEMBL24833582 | 0.74 | JAK3 (0.37) | JAK3LCKBTKEGFR | |
| SCHEMBL16764192 | 0.72 | JAK3 (0.53) | JAK3LCKBTKEGFR | |
| SCHEMBL16764194 | 0.72 | JAK3 (0.53) | JAK3LCKBTKEGFR | |
| SCHEMBL29871862 | 0.72 | JAK3 (0.53) | JAK3LCKBTKEGFR | |
| SCHEMBL30160897 | 0.72 | JAK3 (0.48) | JAK3LCKBTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4342892-A1 | BRUTON'S TYROSINE KINASE AND MUTANT DEGRADER, COMPOSITION AND APPLICATION THEREOF | Hangzhou Healzen Therapeutics Co., Ltd. (CN) | 2024-03-27 | — | — | EP | disclosed |