Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 5/20 | 0.37 |
| ▸ | JAK3 | P52333 | 5/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30827930 | 0.90 | KDM4E (0.38) | KDM4EKMT2AHSD17B10MEN1CASP1 | |
| SCHEMBL24834051 | 0.90 | KDM4E (0.38) | KDM4EKMT2AHSD17B10MEN1CASP1 | |
| SCHEMBL24833595 | 0.77 | JAK3 (0.43) | LCKJAK3BTKEGFR | |
| SCHEMBL24833597 | 0.77 | JAK3 (0.40) | LCKJAK3BTKDPP4KDM1A | |
| SCHEMBL30160897 | 0.73 | JAK3 (0.48) | LCKJAK3BTKEGFR | |
| SCHEMBL30160648 | 0.71 | JAK3 (0.42) | LCKJAK3BTKEGFR | |
| SCHEMBL24833599 | 0.71 | JAK3 (0.42) | LCKJAK3BTKEGFR | |
| SCHEMBL31097402 | 0.71 | JAK3 (0.37) | LCKJAK3BTKEGFR | |
| SCHEMBL30356545 | 0.68 | JAK3 (0.48) | LCKJAK3BTKEGFR | |
| SCHEMBL24833582 | 0.68 | JAK3 (0.37) | LCKJAK3BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023274390-A1 | BRUTON'S TYROSINE KINASE AND MUTANT DEGRADER, COMPOSITION AND APPLICATION THEREOF | 杭州和正医药有限公司 | 2023-01-05 | — | — | WO | disclosed |