Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.57 |
| ▸ | ESR1 | P03372 | 7/20 | 0.57 |
| ▸ | IKZF2 | Q9UKS7 | 6/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | WIZ | O95785 | 1/20 | 0.45 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27194437 | 1.00 | CRBN (0.57) | CRBNESR1IKZF2DDB1AR | |
| SCHEMBL31129522 | 0.98 | CRBN (0.57) | CRBNESR1IKZF2DDB1AR | |
| SCHEMBL22581062 | 0.97 | CRBN (0.57) | CRBNESR1IKZF2DDB1AR | |
| SCHEMBL30942356 | 0.97 | CRBN (0.57) | CRBNESR1IKZF2DDB1AR | |
| SCHEMBL30906233 | 0.96 | CRBN (0.56) | CRBNESR1IKZF2DDB1AR | |
| SCHEMBL34467151 | 0.95 | CRBN (0.54) | CRBNESR1IKZF2DDB1AR | |
| SCHEMBL30906205 | 0.95 | CRBN (0.55) | CRBNESR1IKZF2DDB1AR | |
| SCHEMBL31129780 | 0.95 | CRBN (0.53) | CRBNESR1IKZF2DDB1AR | |
| SCHEMBL30942475 | 0.94 | IKZF2 (0.51) | CRBNESR1IKZF2DDB1WIZ | |
| SCHEMBL31134759 | 0.94 | CRBN (0.50) | CRBNESR1IKZF2DDB1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4584258-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2025-07-16 | — | — | EP | disclosed |
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |