SCHEMBL30906233

SCHEMBL30906233

CC(C)(C)OC(=O)N1CCC(CN2CCC(CN3CCN(c4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)CC2)CC1

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 11/20 0.56
▸ ESR1 P03372 7/20 0.56
▸ IKZF2 Q9UKS7 6/20 0.54
▸ DDB1 Q16531 1/20 0.48
▸ AR P10275 1/20 0.46
▸ IKZF1 Q13422 2/20 0.46
▸ WIZ O95785 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22581062 0.99 CRBN (0.57) CRBNESR1IKZF2DDB1AR
SCHEMBL30942356 0.99 CRBN (0.57) CRBNESR1IKZF2DDB1AR
SCHEMBL31129522 0.98 CRBN (0.57) CRBNESR1IKZF2DDB1AR
SCHEMBL30906205 0.97 CRBN (0.55) CRBNESR1IKZF2DDB1AR
SCHEMBL27314017 0.96 CRBN (0.53) CRBNESR1IKZF2DDB1AR
SCHEMBL27194437 0.96 CRBN (0.57) CRBNESR1IKZF2DDB1AR
SCHEMBL30828166 0.96 CRBN (0.57) CRBNESR1IKZF2DDB1AR
SCHEMBL31129780 0.95 CRBN (0.53) CRBNESR1IKZF2DDB1AR
SCHEMBL30942431 0.95 CRBN (0.52) CRBNESR1IKZF2DDB1AR
SCHEMBL30942513 0.95 CRBN (0.53) CRBNESR1IKZF2DDB1AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4598905-A2 CEREBLON-RECRUITING BCL-XL/BCL-2 DUAL DEGRADERS University of Florida Research Foundation, Incorporated (US) 2025-08-13 — — EP disclosed
WO-2024077023-A2 CEREBLON-RECRUITING BCL-XL/BCL-2 DUAL DEGRADERS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2024-04-11 — — WO disclosed
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