Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 8/20 | 0.52 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30828750 | 1.00 | SIGMAR1 (0.54) | SIGMAR1HTR2ASSTR4HTR2CITGB3 | |
| SCHEMBL30828771 | 1.00 | SIGMAR1 (0.54) | SIGMAR1HTR2ASSTR4HTR2CITGB3 | |
| SCHEMBL30828775 | 1.00 | SIGMAR1 (0.54) | SIGMAR1HTR2ASSTR4HTR2CITGB3 | |
| Hydrochloric Acid SCHEMBL30828783 | 0.99 | SIGMAR1 (0.53) | SIGMAR1HTR2ASSTR4HTR2CITGB3 | |
| Hydrochloric Acid SCHEMBL31533700 | 0.99 | SIGMAR1 (0.53) | SIGMAR1HTR2ASSTR4HTR2CITGB3 | |
| Hydrochloric Acid SCHEMBL30828780 | 0.99 | SIGMAR1 (0.53) | SIGMAR1HTR2ASSTR4HTR2CITGB3 | |
| SCHEMBL29707340 | 0.89 | SIGMAR1 (0.54) | SIGMAR1HTR2AHTR2CTSHRCHRM2 | |
| SCHEMBL4440050 | 0.85 | HTR2A (0.67) | SIGMAR1HTR2AHTR2CCHRM3CYP2D6 | |
| SCHEMBL30828762 | 0.85 | SIGMAR1 (0.53) | SIGMAR1HTR2AHTR2CITGB3ITGA2B | |
| SCHEMBL30828740 | 0.85 | SIGMAR1 (0.53) | SIGMAR1HTR2AHTR2CITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240116892-A1 | HETEROCYCLIC AMIDE AND UREA COMPOUNDS AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. | 2024-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240116892-A1 | HETEROCYCLIC AMIDE AND UREA COMPOUNDS AS JAK2 INHIBITORS | JAK2, JAK1, JAK3 | SIGMAR1 2217/4885HTR2A 2710/4885SSTR4 1163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.