Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | CCR5 | P51681 | 3/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13739933 | 0.90 | SIGMAR1 (0.56) | SIGMAR1CCR5CHRM2CHRM5CHRM1 | |
| SCHEMBL13738840 | 0.90 | SIGMAR1 (0.56) | SIGMAR1CCR5CHRM2CHRM5CHRM1 | |
| SCHEMBL3671431 | 0.90 | SIGMAR1 (0.56) | SIGMAR1CCR5CHRM2CHRM5CHRM1 | |
| SCHEMBL17700060 | 0.87 | SIGMAR1 (0.57) | SIGMAR1CCR5CHRM2CHRM5CHRM1 | |
| SCHEMBL785198 | 0.86 | SIGMAR1 (0.58) | SIGMAR1CCR5CHRM2CHRM5CHRM1 | |
| SCHEMBL17438170 | 0.86 | SIGMAR1 (0.52) | SIGMAR1CCR5CHRM2CHRM5CHRM1 | |
| SCHEMBL25257016 | 0.86 | SIGMAR1 (0.61) | SIGMAR1CCR5CHRM2CHRM5CHRM1 | |
| SCHEMBL25257018 | 0.86 | SIGMAR1 (0.61) | SIGMAR1CCR5CHRM2CHRM5CHRM1 | |
| SCHEMBL29593677 | 0.85 | JAK2 (0.51) | SIGMAR1CCR5SMN1; SMN2NPC1RAB9A | |
| SCHEMBL31748093 | 0.84 | SIGMAR1 (0.47) | SIGMAR1CCR5CHRM2CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024034591-A1 | HETEROCYCLIC COMPOUND FOR INHIBITING AND/OR INDUCING DEGRADATION OF KRAS PROTEIN | アステラス製薬株式会社 | 2024-02-15 | — | — | WO | disclosed |