Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8853760 | 0.86 | ALDH1A1 (0.44) | HSD17B10GLAALDH1A1KDM4EHTT | |
| SCHEMBL31628212 | 0.83 | NOX1 (0.35) | KDM4ESMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL10353392 | 0.80 | ALDH1A1 (0.49) | HSD17B10GLAALDH1A1KDM4EHTT | |
| SCHEMBL31628162 | 0.78 | HTT (0.39) | HSD17B10ALDH1A1HTTTSHRTDP1 | |
| SCHEMBL29073421 | 0.77 | BRD4 (0.44) | ALOX15NPC1BRD4CREBBPIDO1 | |
| SCHEMBL8802497 | 0.74 | HSD17B10 (0.49) | HSD17B10GLAALDH1A1KDM4EHTT | |
| SCHEMBL8905187 | 0.74 | ALDH1A1 (0.49) | HSD17B10GLAALDH1A1KDM4EHTT | |
| SCHEMBL4800295 | 0.74 | ALDH1A1 (0.49) | HSD17B10GLAALDH1A1KDM4EHTT | |
| SCHEMBL4495147 | 0.74 | ALDH1A1 (0.49) | HSD17B10GLAALDH1A1KDM4EHTT | |
| SCHEMBL28704834 | 0.73 | ALDH1A1 (0.40) | HSD17B10ALDH1A1KDM4EHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4568958-A1 | BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-06-18 | — | — | EP | disclosed |
| WO-2024033388-A1 | BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-02-15 | — | — | WO | disclosed |