Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 4/20 | 0.51 |
| ▸ | KAT2B | Q92831 | 16/20 | 0.50 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.44 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.44 |
| ▸ | BRD1 | O95696 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | BPTF | Q12830 | 1/20 | 0.40 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.40 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30830669 | 0.94 | CRBN (0.51) | CRBNKAT2BBRD9DDB1IKZF3 | |
| SCHEMBL30830919 | 0.93 | CRBN (0.50) | CRBNKAT2BBRD9DDB1IKZF3 | |
| SCHEMBL30830747 | 0.90 | KAT2B (0.51) | CRBNKAT2BBRD9DDB1IKZF3 | |
| SCHEMBL30830529 | 0.88 | KAT2B (0.49) | KAT2BBRD9 | |
| SCHEMBL30830602 | 0.87 | KAT2B (0.55) | CRBNKAT2BBRD9BRD1ACHE | |
| SCHEMBL30830885 | 0.87 | KAT2B (0.55) | KAT2BBRD9BRD1ACHEBRPF1 | |
| SCHEMBL30830642 | 0.84 | PLK4 (0.46) | CRBNKAT2BBRD9DDB1IKZF3 | |
| SCHEMBL30830707 | 0.83 | KAT2B (0.51) | CRBNKAT2BBRD9DDB1IKZF3 | |
| SCHEMBL30830574 | 0.83 | IKZF2 (0.49) | CRBNKAT2BBRD9IKZF3 | |
| SCHEMBL30831023 | 0.82 | KAT2B (0.55) | KAT2BBRD9BPTF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4581025-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Auron Therapeutics, Inc. (US) | 2025-07-09 | — | — | EP | disclosed |
| WO-2024050078-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AURON THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |