Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15290689 | 1.00 | PTGS1 (0.60) | PTGS1PTGS2HDAC4HDAC7HDAC5 | |
| SCHEMBL27984140 | 0.85 | HDAC4 (0.46) | PTGS1PTGS2HDAC4HDAC7HDAC5 | |
| SCHEMBL28471244 | 0.84 | HDAC4 (0.53) | PTGS1PTGS2HDAC4HDAC7HDAC5 | |
| SCHEMBL13194421 | 0.83 | LMNA (0.46) | PTGS1PTGS2HDAC4HDAC7HDAC5 | |
| SCHEMBL27616860 | 0.83 | HDAC4 (0.45) | PTGS1PTGS2HDAC4HDAC7HDAC5 | |
| SCHEMBL4217690 | 0.83 | FFAR1 (0.49) | PTGS1PTGS2KDM4E | |
| SCHEMBL27677932 | 0.82 | HDAC4 (0.47) | PTGS1PTGS2HDAC4HDAC7HDAC5 | |
| SCHEMBL7395276 | 0.82 | HDAC4 (0.53) | PTGS1PTGS2HDAC4HDAC7HDAC5 | |
| SCHEMBL25940541 | 0.82 | PTGS1 (0.46) | PTGS1PTGS2CES2CES1KMT2A | |
| SCHEMBL15084962 | 0.81 | HDAC4 (0.50) | PTGS1PTGS2HDAC4HDAC7HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112752757-B | Tyrosine amide derivatives as RHO-kinase inhibitors | 奇斯药制品公司 | 2024-01-12 | — | — | CN | disclosed |