Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 5/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18392380 | 1.00 | USP2 (0.41) | USP2SMN1; SMN2PTPN11EPHX2GPR119 | |
| SCHEMBL20337474 | 1.00 | USP2 (0.41) | USP2SMN1; SMN2PTPN11EPHX2GPR119 | |
| SCHEMBL30197470 | 1.00 | USP2 (0.41) | USP2SMN1; SMN2PTPN11EPHX2GPR119 | |
| SCHEMBL18328440 | 1.00 | USP2 (0.41) | USP2SMN1; SMN2PTPN11EPHX2GPR119 | |
| SCHEMBL30197520 | 0.87 | USP2 (0.39) | USP2SMN1; SMN2EPHX2GPR119RECQL | |
| SCHEMBL16914196 | 0.86 | PTPN11 (0.41) | PTPN11 | |
| SCHEMBL21631388 | 0.86 | PTPN11 (0.41) | PTPN11 | |
| SCHEMBL22799125 | 0.86 | PTPN11 (0.41) | PTPN11 | |
| SCHEMBL22016006 | 0.86 | USP2 (0.39) | USP2SMN1; SMN2PTPN11EPHX2GPR119 | |
| SCHEMBL31336383 | 0.83 | EPHX1 (0.40) | USP2SMN1; SMN2EPHX2GPR119RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112625028-B | Compounds and compositions for inhibiting SHP2 activity | 诺华股份有限公司 | 2024-10-29 | — | — | CN | disclosed |
| CN-115448923-B | Pyrimidine-fused ring compound, preparation method and application thereof | 上海青煜医药科技有限公司 | 2024-03-22 | — | — | CN | disclosed |