Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 7/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18392380 | 0.86 | USP2 (0.41) | USP2SMN1; SMN2RECQLGPR119EPHX2 | |
| SCHEMBL30833164 | 0.86 | USP2 (0.41) | USP2SMN1; SMN2RECQLGPR119EPHX2 | |
| SCHEMBL30197470 | 0.86 | USP2 (0.41) | USP2SMN1; SMN2RECQLGPR119EPHX2 | |
| SCHEMBL18328440 | 0.86 | USP2 (0.41) | USP2SMN1; SMN2RECQLGPR119EPHX2 | |
| SCHEMBL20337474 | 0.86 | USP2 (0.41) | USP2SMN1; SMN2RECQLGPR119EPHX2 | |
| SCHEMBL16914302 | 0.85 | EPHX1 (0.36) | USP2SMN1; SMN2GPR119EPHX2NAMPT | |
| SCHEMBL21851991 | 0.85 | EPHX1 (0.36) | USP2SMN1; SMN2GPR119EPHX2NAMPT | |
| SCHEMBL21851984 | 0.83 | GPR119 (0.34) | USP2SMN1; SMN2GPR119EPHX2NAMPT | |
| SCHEMBL21851847 | 0.79 | KDM1A (0.41) | GPR119NAMPT | |
| SCHEMBL31336383 | 0.78 | EPHX1 (0.40) | USP2SMN1; SMN2RECQLGPR119EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468972-B1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2020-05-20 | — | — | EP | disclosed |