Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | KDM4B | O94953 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | TYMP | P19971 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25223292 | 1.00 | POLB (0.50) | POLBPIM1PIM2PARP1PRMT5 | |
| SCHEMBL25581256 | 0.85 | POLB (0.51) | POLBPIM1PIM2PARP1PRMT5 | |
| SCHEMBL29915166 | 0.84 | POLB (0.54) | POLBPIM1PIM2PARP1PRMT5 | |
| SCHEMBL27002538 | 0.84 | POLB (0.54) | POLBPIM1PIM2PARP1PRMT5 | |
| SCHEMBL30833177 | 0.82 | PRMT5 (0.35) | PARP1PRMT5WDR77ADORA1PDE1A | |
| SCHEMBL25219373 | 0.82 | PRMT5 (0.35) | PARP1PRMT5WDR77ADORA1PDE1A | |
| SCHEMBL31496951 | 0.82 | PRMT5 (0.46) | PRMT5WDR77 | |
| SCHEMBL23087512 | 0.82 | ADORA1 (0.44) | PARP1PRMT5WDR77ADORA1PDE1A | |
| SCHEMBL29915218 | 0.80 | POLB (0.46) | POLBPIM1PIM2PARP1PRMT5 | |
| SCHEMBL27002563 | 0.80 | POLB (0.46) | POLBPIM1PIM2PARP1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117730075-A | Pyrazole derivative, preparation method and pharmaceutical application thereof | 上海和誉生物医药科技有限公司 | 2024-03-19 | — | — | CN | disclosed |