Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.41 |
| ▸ | CDK19 | Q9BWU1 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29190630 | 0.84 | EGFR (0.54) | JAK2JAK3ALKCDK19CDK2 | |
| SCHEMBL30833758 | 0.84 | SYK (0.46) | JAK2JAK3JAK1ALKCDK19 | |
| SCHEMBL29190703 | 0.83 | EGFR (0.49) | JAK2JAK3ALKCDK19CDK2 | |
| SCHEMBL30833768 | 0.80 | ALK (0.46) | JAK2JAK3JAK1ALKCDK19 | |
| SCHEMBL30833779 | 0.79 | EGFR (0.48) | ALKCDK19CDK2GSK3BSYK | |
| SCHEMBL30833636 | 0.79 | ALK (0.42) | JAK2JAK3JAK1ALKCDK19 | |
| SCHEMBL30833709 | 0.79 | CDK1 (0.55) | ALKCDK19GSK3BSYKCLK2 | |
| SCHEMBL30833740 | 0.77 | PTK2 (0.50) | JAK2JAK3CDK2GSK3BCDC7 | |
| SCHEMBL29190628 | 0.76 | IGF1R (0.46) | MAPK8IGF1R | |
| SCHEMBL30833673 | 0.76 | SYK (0.45) | JAK2JAK3JAK1ALKCDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113896744-B | Selective EGFR inhibitor | 成都先导药物开发股份有限公司 | 2024-04-16 | — | — | CN | disclosed |