Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.50 |
| ▸ | ULK1 | O75385 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 7/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | PAK4 | O96013 | 2/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | PRKACA | P17612 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.45 |
| ▸ | CLK2 | P49760 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.45 |
| ▸ | STK3 | Q13188 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29190561 | 0.80 | EGFR (0.52) | EGFRFGFR1ZAP70SYKCDK2 | |
| SCHEMBL30833756 | 0.79 | EGFR (0.57) | EGFRFGFR1ZAP70SYKCDK2 | |
| SCHEMBL29190600 | 0.79 | EGFR (0.57) | EGFRFGFR1ZAP70SYKCDK2 | |
| SCHEMBL30833657 | 0.78 | ZAP70 (0.43) | EGFRFGFR1ZAP70ULK1SYK | |
| SCHEMBL29190651 | 0.78 | EGFR (0.54) | EGFRFGFR1ZAP70SYKCDK2 | |
| SCHEMBL30833624 | 0.78 | EGFR (0.54) | EGFRFGFR1ZAP70SYKCDK2 | |
| SCHEMBL29190543 | 0.77 | EGFR (0.51) | EGFRFGFR1ZAP70SYKCDK2 | |
| SCHEMBL30833764 | 0.74 | IGF1R (0.45) | EGFRFGFR1ULK1SYKCDK2 | |
| SCHEMBL30833738 | 0.74 | ALK (0.63) | EGFRFGFR1ZAP70ULK1PRKD3 | |
| SCHEMBL6210042 | 0.72 | PTK2 (0.55) | EGFRFGFR1ULK1SYKDAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113896744-B | Selective EGFR inhibitor | 成都先导药物开发股份有限公司 | 2024-04-16 | — | — | CN | disclosed |