Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 6/20 | 0.46 |
| ▸ | VEGFA | P15692 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | BCL2 | P10415 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30834662 | 0.88 | MEN1 (0.43) | BCL2L1VEGFAEGLN1BCL2MEN1 | |
| SCHEMBL25423208 | 0.86 | BCL2L1 (0.67) | BCL2L1BCL2MEN1KMT2AHTT | |
| SCHEMBL25422237 | 0.86 | BCL2L1 (0.67) | BCL2L1BCL2MEN1KMT2AHTT | |
| SCHEMBL1955791 | 0.85 | BCL2L1 (0.61) | BCL2L1VEGFAEGLN1BCL2MEN1 | |
| SCHEMBL22325103 | 0.84 | BCL2L1 (0.55) | BCL2L1BCL2MEN1KMT2AHTT | |
| SCHEMBL30834667 | 0.82 | SMN1; SMN2 (0.43) | BCL2L1VEGFAEGLN1MEN1KMT2A | |
| SCHEMBL24483105 | 0.81 | BCL2L1 (0.52) | BCL2L1BCL2MEN1KMT2AHTT | |
| SCHEMBL25422517 | 0.81 | BCL2L1 (0.61) | BCL2L1BCL2HTTSMN1; SMN2NPSR1 | |
| SCHEMBL25422247 | 0.81 | BCL2L1 (0.61) | BCL2L1BCL2HTTSMN1; SMN2NPSR1 | |
| SCHEMBL25422108 | 0.81 | BCL2L1 (0.59) | BCL2L1BCL2KMT2AHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117886881-A | Chimeric compound for targeted degradation of BCL-2 protein, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2024-04-16 | — | — | CN | disclosed |