Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | VEGFA | P15692 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22325103 | 0.84 | BCL2L1 (0.55) | SMN1; SMN2HTTCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL30834662 | 0.84 | MEN1 (0.43) | SMN1; SMN2HTTCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL24483105 | 0.82 | BCL2L1 (0.52) | SMN1; SMN2HTTCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL30834646 | 0.82 | BCL2L1 (0.46) | SMN1; SMN2HTTCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL22325296 | 0.81 | BCL2L1 (0.52) | SMN1; SMN2HTTCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL25420906 | 0.80 | BCL2L1 (0.51) | SMN1; SMN2HTTALDH1A1KMT2AMEN1 | |
| SCHEMBL25717095 | 0.80 | BCL2L1 (0.51) | SMN1; SMN2HTTALDH1A1KMT2AMEN1 | |
| SCHEMBL25717307 | 0.80 | BCL2L1 (0.49) | SMN1; SMN2HTTCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL22325068 | 0.79 | BCL2L1 (0.51) | SMN1; SMN2HTTALDH1A1KMT2AMEN1 | |
| SCHEMBL25717383 | 0.79 | BCL2L1 (0.49) | SMN1; SMN2HTTCYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117886881-A | Chimeric compound for targeted degradation of BCL-2 protein, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2024-04-16 | — | — | CN | disclosed |