Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 1/20 | 0.52 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.46 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30834665 | 0.85 | VEGFA (0.56) | VEGFAEGLN1NPSR1HTTSMN1; SMN2 | |
| SCHEMBL23301852 | 0.84 | ALDH1A1 (0.49) | VEGFAEGLN1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL29943231 | 0.84 | ALDH1A1 (0.49) | VEGFAEGLN1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL1955369 | 0.84 | HCRTR1 (0.56) | HCRTR1HCRTR2GAAMAPTHPGD | |
| SCHEMBL32667348 | 0.84 | VEGFA (0.64) | VEGFAEGLN1NPSR1HTTSMN1; SMN2 | |
| SCHEMBL5536182 | 0.83 | VEGFA (0.68) | VEGFAEGLN1GAAMAPTHPGD | |
| SCHEMBL26648127 | 0.82 | SMN1; SMN2 (0.56) | VEGFAEGLN1HCRTR1HCRTR2GAA | |
| SCHEMBL31450827 | 0.82 | SMN1; SMN2 (0.56) | VEGFAEGLN1HCRTR1HCRTR2GAA | |
| SCHEMBL25487258 | 0.82 | ALDH1A1 (0.53) | VEGFAEGLN1NPSR1SMN1; SMN2TP53 | |
| SCHEMBL20567000 | 0.82 | ALDH1A1 (0.45) | VEGFAEGLN1MAPTNPSR1PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117886881-A | Chimeric compound for targeted degradation of BCL-2 protein, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2024-04-16 | — | — | CN | disclosed |