SCHEMBL30835907

SCHEMBL30835907

C=CC(=O)N1CC[C@](O)(C#Cc2ccc(C(F)(F)F)cc2)C1

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GPR183 P32249 2/20 0.44
BTK Q06187 1/20 0.43
TEAD1 P28347 10/20 0.42
SMN1; SMN2 Q16637 2/20 0.37
HPGD P15428 1/20 0.37
TET3 O43151 1/20 0.36
KMT2A Q03164 1/20 0.36
FBXL19 Q6PCT2 1/20 0.36
CXXC5 Q7LFL8 1/20 0.36
TET1 Q8NFU7 1/20 0.36
KDM2B Q8NHM5 1/20 0.36
CXXC4 Q9H2H0 1/20 0.36
KDM2A Q9Y2K7 1/20 0.36
USP2 O75604 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C19 P33261 1/20 0.35
EPHX2 P34913 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27399905 1.00 GPR183 (0.44) GPR183BTKTEAD1SMN1; SMN2HPGD
SCHEMBL31556538 1.00 GPR183 (0.44) GPR183BTKTEAD1SMN1; SMN2HPGD
SCHEMBL31556516 1.00 GPR183 (0.44) GPR183BTKTEAD1SMN1; SMN2HPGD
Trifluoroacetic Acid SCHEMBL30836053 0.96 GPR183 (0.44) GPR183BTKTEAD1SMN1; SMN2TET3
SCHEMBL27399998 0.93 TEAD1 (0.46) GPR183BTKTEAD1SMN1; SMN2HPGD
SCHEMBL31556495 0.87 BTK (0.46) GPR183BTKTEAD1SMN1; SMN2TET3
SCHEMBL31556565 0.87 BTK (0.46) GPR183BTKTEAD1SMN1; SMN2TET3
SCHEMBL30835915 0.87 BTK (0.46) GPR183BTKTEAD1SMN1; SMN2TET3
SCHEMBL27399901 0.87 BTK (0.46) GPR183BTKTEAD1SMN1; SMN2TET3
SCHEMBL30836014 0.85 GPR183 (0.44) GPR183BTKTEAD1TET3KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4587424-A1 YAP/TAZ-TEAD ONCOPROTEINS INHIBITORS Bridgene Biosciences, Inc. (US) 2025-07-23 EP disclosed
WO-2024059317-A1 YAP/TAZ-TEAD ONCOPROTEINS INHIBITORS BRIDGENE BIOSCIENCES, INC. (US) 2024-03-21 WO disclosed