Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30836826 | 0.81 | PTGER4 (0.43) | KDM4ERXFP1HDAC1NPC1RAB9A | |
| SCHEMBL149172 | 0.80 | AGER (0.53) | NPC1RAB9AMAPTSMN1; SMN2HPGD | |
| SCHEMBL19785837 | 0.76 | KDR (0.46) | KDM4ERXFP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19779555 | 0.75 | ATM (0.43) | KDM4ERXFP1NPC1RAB9AMAPT | |
| SCHEMBL31145808 | 0.75 | PDCD1 (0.49) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL20539477 | 0.75 | PDCD1 (0.49) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL16320563 | 0.75 | NPC1 (0.50) | KDM4ERXFP1HDAC1NPC1RAB9A | |
| SCHEMBL19986428 | 0.74 | AVPR2 (0.51) | KDM4ERXFP1NPC1RAB9AMAPT | |
| SCHEMBL29782472 | 0.74 | NPC1 (0.49) | KDM4EHDAC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16320407 | 0.74 | NPC1 (0.49) | KDM4EHDAC1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024069448-A1 | SUBSTITUTED 1-ARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1-HETEROARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2024-04-04 | — | — | WO | disclosed |