Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 9/20 | 0.50 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30836769 | 0.89 | LIPE (0.50) | LIPEPDCD1CD274NPC1 | |
| SCHEMBL31096107 | 0.86 | PDCD1 (0.49) | LIPEPDCD1CD274 | |
| SCHEMBL28793298 | 0.82 | LIPE (0.52) | LIPECD274CXCR2MEN1AHR | |
| SCHEMBL20293126 | 0.81 | LIPE (0.50) | LIPEPDCD1CD274PTPN11CXCR2 | |
| SCHEMBL30836715 | 0.81 | LIPE (0.50) | LIPEPDCD1CD274PTPN11CXCR2 | |
| SCHEMBL25891782 | 0.78 | LIPE (0.46) | LIPEPDCD1CD274SMN1; SMN2NPC1 | |
| SCHEMBL31354155 | 0.76 | PDCD1 (0.51) | LIPEPDCD1CD274 | |
| SCHEMBL20293718 | 0.76 | P4HTM (0.40) | PDCD1CD274SMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL31353784 | 0.76 | P4HTM (0.40) | PDCD1CD274SMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL21623038 | 0.75 | LIPE (0.45) | LIPEPDCD1CD274MEN1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024069448-A1 | SUBSTITUTED 1-ARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1-HETEROARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2024-04-04 | — | — | WO | disclosed |