Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 6/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3083908 | 0.89 | USP7 (0.41) | USP7CCNCCDK8KDM4EPSEN1 | |
| SCHEMBL3076257 | 0.84 | USP7 (0.43) | USP7KDM4ENPC1POLBRAB9A | |
| SCHEMBL3089794 | 0.78 | USP7 (0.44) | USP7HDAC6KDM4ENPC1POLB | |
| SCHEMBL3087167 | 0.77 | PTGS1 (0.52) | USP7CCNCCDK8KDM4EHTT | |
| SCHEMBL3077086 | 0.76 | CNR2 (0.44) | USP7KDM4E | |
| SCHEMBL3077814 | 0.76 | FYN (0.46) | KDM4EPOLBALDH1A1 | |
| SCHEMBL3077074 | 0.76 | MAPK1 (0.47) | USP7KDM4ENPC1GAAALDH1A1 | |
| SCHEMBL3095735 | 0.75 | MCHR1 (0.47) | — | |
| SCHEMBL3084803 | 0.74 | CNR2 (0.50) | ADK | |
| SCHEMBL3081742 | 0.73 | USP7 (0.46) | USP7KDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100227880-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2010-09-09 | — | — | US | disclosed |
| EP-1984375-A2 | CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087548-A9 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-09-27 | — | — | WO | disclosed |
| WO-2007087548-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227880-A1 | CHEMICAL COMPOUNDS | CYP3A5, SLC10A1, ABCB11 | USP7 3872/4885HDAC6 111/4885CCNC 3001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.