Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.54 |
| ▸ | TLR7 | Q9NYK1 | 14/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20475982 | 1.00 | NLRP3 (0.54) | NLRP3TLR7TLR8KCNH2GAA | |
| SCHEMBL30842213 | 0.85 | KCNH2 (0.44) | NLRP3KCNH2GAAMAPTHSD17B10 | |
| SCHEMBL20741495 | 0.85 | KCNH2 (0.44) | NLRP3KCNH2GAAMAPTHSD17B10 | |
| SCHEMBL20762168 | 0.84 | NLRP3 (0.78) | NLRP3TLR7TLR8KCNH2 | |
| SCHEMBL26862594 | 0.83 | NLRP3 (0.59) | NLRP3TLR7TLR8 | |
| SCHEMBL20762166 | 0.81 | TLR7 (0.55) | NLRP3TLR7TLR8 | |
| SCHEMBL30842202 | 0.79 | KCNH2 (0.42) | KCNH2GAAMAPTHSD17B10 | |
| SCHEMBL20475984 | 0.79 | KCNH2 (0.42) | KCNH2GAAMAPTHSD17B10 | |
| SCHEMBL21949601 | 0.78 | TLR7 (0.55) | TLR7TLR8 | |
| SCHEMBL20761874 | 0.78 | NLRP3 (0.52) | NLRP3TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110325534-B | Substituted imidazoquinolines as NLRP3 modulators | 先天肿瘤免疫公司 | 2024-04-05 | — | — | CN | disclosed |